- Sotagliflozin;LX-4211
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- $0.00 / 1kg
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2024-05-29
- CAS:1018899-04-1
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 500kg
- LX-4211
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- $1.00 / 1g
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2024-05-24
- CAS:1018899-04-1
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1000
Related articles - How to synthesize Sotagliflozin?
- Sotagliflozin (LX-4211) is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (....
- Jan 16，2024
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| | LX-4211 Basic information |
| Product Name: | LX-4211 | | Synonyms: | LX-4211;(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside;LX4211/LX-4211;LP 802034;LX4211 - L10525;LX-4211 (sotagliflozin);LX-4211, >=98% | | CAS: | 1018899-04-1 | | MF: | C21H25ClO5S | | MW: | 424.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1018899-04-1.mol |  |
| | LX-4211 Chemical Properties |
| Boiling point | 607.9±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM)
Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM) | | pka | 12.87±0.70(Predicted) | | form | Powder |
| | LX-4211 Usage And Synthesis |
| Uses | Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus. | | Clinical Use | Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption. | | Synthesis | Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis |
| | LX-4211 Preparation Products And Raw materials |
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