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| | 1-BENZOYL-3-PHENYL-2-THIOUREA Basic information |
| Product Name: | 1-BENZOYL-3-PHENYL-2-THIOUREA | | Synonyms: | 1-benzoyl-3-phenyl-2-thio-ure;n-phenylthiocarbamoyl-benzamid;phenylbenzoylthiourea;usafk-1473;1-Benzoyl-3-phenyl(thiourea);1-Benzoyl-3-phenylthiourea;N-(Phenylthiocarbamoyl)benzamide;N-Benzoyl-N'-phenylthiourea | | CAS: | 4921-82-8 | | MF: | C14H12N2OS | | MW: | 256.32 | | EINECS: | | | Product Categories: | | | Mol File: | 4921-82-8.mol |  |
| | 1-BENZOYL-3-PHENYL-2-THIOUREA Chemical Properties |
| Melting point | 159 °C | | density | 1.290±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml). | | form | solid | | pka | 9.49±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 4921-82-8(CAS DataBase Reference) |
| HazardClass | IRRITANT | | HS Code | 2930909899 |
| | 1-BENZOYL-3-PHENYL-2-THIOUREA Usage And Synthesis |
| Description | TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants?in vitro.2 | | References | 1) Singh?et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg. Med. Chem. Lett.,?21?5920
2) Decross?et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem. Biol.,?9?2157
3) Singh?et al. (2015),?Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels; J. Biol. Chem.,?290?6607 |
| | 1-BENZOYL-3-PHENYL-2-THIOUREA Preparation Products And Raw materials |
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