| Company Name: |
United States Biological
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| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:Morphazinamide
CAS:952-54-5
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| | morinamide Basic information |
| Product Name: | morinamide | | Synonyms: | morinamide;morphazinamide;B 2310;Morfazinamide;N-(Morpholinomethyl)-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, N-(4-morpholinylmethyl)-;pyrazine-2-carboxylic acid morpholin-4-ylmethyl-amide | | CAS: | 952-54-5 | | MF: | C10H14N4O2 | | MW: | 222.24 | | EINECS: | 213-460-4 | | Product Categories: | | | Mol File: | 952-54-5.mol |  |
| | morinamide Chemical Properties |
| Melting point | 118.5-119.5° |
| | morinamide Usage And Synthesis |
| Originator | Morinamide,Bracco Industria Chimica
S.p.A. | | Uses | Morphazinamide is an anti-tuberculosis agent. Also, it is derived from Pyrazinamide (P840600), which is an anti-bacterial (tuberculostatic). | | Definition | ChEBI: Morinamide is a member of pyrazines, a secondary carboxamide and a member of morpholines. | | Manufacturing Process | 98.5 parts by weight 2-pyrazinecarboxamide was mixed with 260 parts by
volume of diethylamine. 91 parts by weight of 37% formaldehyde was added
to above mixture by stirring for 30 minutes. The reaction mixture was
spontaneously heated to 50°C. Then it heated to reflux for 5 hours on water
bath. After that it was distilled to dryness at temperature between 40°-50°C.
The residue was dissolved with about 200 parts by volume of ligroin (B.P.
60°C) by heating. The solution was filtered hot for removing the not reacted
2-pyrazinecarboxamide. Then it was cooled to -10°C and desired N-
(diethylaminomethyl)-pyrazinecarboxylic acid amide discharged. It was filtered
off and recrystallized from light petrol ester. Yield about 90%, MP: 47°-50°C.
500 parts by weight of N-(diethylaminomethyl)pyrazinecarboxylic acid amide
and 2500 parts by volume of was mixed and heated by stirring to temperature
140°-150°C. At 60°-100°C a distillation begun and ended at 127°C (a boiling
point of morpholine). The distillate consisted from diethylamine and
morpholine. After 30-60 minutes the mixture was cooled to 50°C and distilled
in vacuum to dryness. The residue was recrystallized from 400 parts by
volume of benzene to give N-(morpholinomethyl)pyrazinecarboxamide, yield
92%, MP: 114°-117°C. | | Therapeutic Function | Antitubercular |
| | morinamide Preparation Products And Raw materials |
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