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Guangzhou Isun Pharmaceutical Co., Ltd
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Product Name:BW A868C
CAS:118675-50-6
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G
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| Company Name: |
BOC Sciences
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16314854226 |
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| Products Intro: |
Product Name:BW A868C
CAS:118675-50-6
Purity:98% Package:1G;10G;100G Remarks:Prostaglandin D2 (PGD2) has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system. BW A868C is a novel, selective and potent com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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| Products Intro: |
Product Name:BW A868C
CAS:118675-50-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
amyjetsci
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027-59626688 18771149750 |
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| Products Intro: |
Product Name:BW A868C
Package:1EA/
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| | BW A868C Basic information |
| Product Name: | BW A868C | | Synonyms: | BW A868C;3-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)-2,5-DIOXO-1-BENZYL-4-IMIDAZOLIDINEHEPTANOIC ACID;(+/-)-3-BENZYL-5-(6-CARBOXYHEXYL)-1-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)HYDANTOIN;7-[3-[(2-CYCLOHEXYL-2-HYDROXYETHYL)AMINO]-2,5-DIOXO-1-(PHENYLMETHYL)-4-IMIDAZOLIDINYL]HEPTANOIC ACID;3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid;4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- | | CAS: | 118675-50-6 | | MF: | C25H37N3O5 | | MW: | 459.58 | | EINECS: | | | Product Categories: | | | Mol File: | 118675-50-6.mol |  |
| | BW A868C Chemical Properties |
| Boiling point | 638.1±65.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: >5 mg/mL, soluble | | form | solid | | pka | 4.77±0.10(Predicted) | | color | colorless |
| | BW A868C Usage And Synthesis |
| Uses | BW A868C is a hydantoin compound structurally related to the DP agonist BW245C. | | Definition | ChEBI: BW A868C is an imidazolidine-2,4-dione. | | Biological Activity | bw a868c is a novel, selective and potent competitive antagonist of prostaglandin d2 (pgd2) [1].prostaglandin d2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. prostaglandin d2 is critical for the development of allergic diseases such as asthma. | | in vitro | in glycerol-lysed human platelets, bw245c activated adenylate cyclase in a biphasic manner. bw a868c showed no effect on carbacyclin, iloprost, prostacyclin, pge1 and pge2 at a concentration 1,000 fold that of its kb against pgd2 and bw245c [1]. bw a868c showed no effect on human tp, ip, ep1, ep2, and fp receptors. the ki value for bw a868c is approximately 1.7 nm[1] .in isolated rings of rabbit saphenous vein (rbsv) pre-contracted with 40 mm kcl, bw245c caused concentration-dependent relaxations with an ec50 of 38 nm [3]. | | references | [1] giles h, leff p, bolofo m l, et al. the classification of prostaglandin dp‐receptors in platelets and vasculature using bw a868c, a novel, selective and potent competitive antagonist[j]. british journal of pharmacology, 1989, 96(2): 291-300.
[2] shimizu t, mizuno n, amano t, et al. prostaglandin d2, a neuromodulator[j]. proceedings of the national academy of sciences, 1979, 76(12): 6231-6234.
[3] lydford s j, mckechnie k c w, leff p. interaction of bw a868c, a prostanoid dp-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[j]. prostaglandins, 1996, 52(2): 125-139. |
| | BW A868C Preparation Products And Raw materials |
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