2'-O-MOE-5MeU-3'-phosphoramidite manufacturers
- 2'-MOE-U CE Phosphoramidite
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- $100.00 / 15kg
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2023-03-21
- CAS:163878-63-5
- Min. Order: 0.009999999776482582kg
- Purity: 99%
- Supply Ability: 5tons
- 5'-O-DMT-2'-O-MOE-T-CE
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- $0.00 / 100mg
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2023-03-14
- CAS:163878-63-5
- Min. Order: 100mg
- Purity: ≥98%
- Supply Ability: 20tons
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| | 2'-O-MOE-5MeU-3'-phosphoramidite Basic information |
| Product Name: | 2'-O-MOE-5MeU-3'-phosphoramidite | | Synonyms: | 5'-O-DMT-2'-O-methyl-5-methyluridine;5-Me-DMT-2'-O-Me-Ur;5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine;2'-O-MOE-5MeU-3'-phosphoramidite;5'-O-DMTR-2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE-3'-CED-PHOSPHORAMIDITE;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-(2-METHOXYETHOXY)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE;2-O-MOE-5-Methyl-Uridine Phosphoramidite | | CAS: | 163878-63-5 | | MF: | C43H55N4O10P | | MW: | 818.89 | | EINECS: | | | Product Categories: | Amidite | | Mol File: | 163878-63-5.mol |  |
| | 2'-O-MOE-5MeU-3'-phosphoramidite Chemical Properties |
| pka | 9.55±0.10(Predicted) | | InChIKey | YFRRKZDUDXHJNC-UHDLEJOUNA-N | | SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,37,43,r| |
| | 2'-O-MOE-5MeU-3'-phosphoramidite Usage And Synthesis |
| Chemical Properties | white to off-white powder | | Uses | 5''-O-DMT-2''-O-methyl-5-methyluridine is a uridine-derived oligonucleoside (U829910) used in the synthetic preparation of nucleic acids. | | General Description |
2'-O-MOE-5MeU-3'-phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
| | General Description | Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U. |
| | 2'-O-MOE-5MeU-3'-phosphoramidite Preparation Products And Raw materials |
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