| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
| Products Intro: |
Product Name:MPP dihydrochloride;1,3-Bis(4-hydroxyphenyl)-4-Methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazoledihydrochloride
CAS:289726-02-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:MPP dihydrochloride
CAS:289726-02-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Shanghai QianYan Bio-technology Co., Ltd
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| Tel: |
02781293128 |
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orders@biochemsafebuy.com |
| Products Intro: |
Product Name:1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE
CAS:289726-02-9
Purity:>98% .NMR+LCMS Package:50Mg/100Mg/500Mg/1g/5g/10g/
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| | 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Basic information |
| | 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Chemical Properties |
| Boiling point | 659.2±55.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO: ≥5 mg/mL, soluble | | form | solid | | pka | 8.80±0.15(Predicted) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Usage And Synthesis |
| Uses | MPP is a high affinity silent antagonist at ERα. | | Biological Activity | Selective, high affinity silent antagonist at ERa receptors. Displays > 200-fold selectivity for ERa over ERb. K i values are 2.7 and 1800 nM at ERa and ERb receptors respectively. | | in vitro | mpp elicited significant apoptosis in the endometrial cancer cell lines, rl-95 cells, and ovine luminal endometrial cell lines relative to the vehicle-treated cells. it was indicated that selective estrogen receptor modulators-induced apoptosis is ascribed to genomic actions instead of toxicity, which was due to the low percentage of apoptosis reduced by the addition of a 10-fold excess of β-estradiol [1]. | | in vivo | wild-type (wt) cf1 and estrogen receptor-β knockout (erbko) female mice were injected intraperitoneally with two dosages 24 hr apart of 100 mg and 150 mg of mpp, 50 mg and 50 mg mpp, respectively. mpp significantly increased uterine weight and cell proliferation when compared to the vehicle control in wt and erbko mice. however, compared to the control groups, mpp did not effectively increase uterine wet weight. mpp treatment of ovariectomized mice activated apoptosis of the underlying uterine stromal cells without triggering apoptosis of the luminal epithelial cells [1]. | | IC 50 | 80 nm: blocks the transcriptional activation of the estrogen receptor (er) α. | | references | [1]. davis, a., ellersieck, m., grimm, k., & rosenfeld, c. the effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (mpp), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. molecular reproduction and development. 2006; 73(8): 1034-1044. |
| | 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Preparation Products And Raw materials |
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