Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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Tel: |
010-60605840 18892239720 |
Email: |
psaitong@jm-bio.com |
Products Intro: |
Product Name:Enniatin complex CAS:11113-62-5 Purity:95% Package:1mg;5mg;10mg
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| ENNIATIN FROM MICROBIAL SOURCE Basic information |
Product Name: | ENNIATIN FROM MICROBIAL SOURCE | Synonyms: | ENNIATIN FROM MICROBIAL SOURCE;Enniatin microbial;Enniatin coMplex;(3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone | CAS: | 11113-62-5 | MF: | C36H63N3O9.C35H61N3O9.C34H59N3O9.C33H57N3O9 | MW: | 2643.46 | EINECS: | | Product Categories: | | Mol File: | 11113-62-5.mol | |
| ENNIATIN FROM MICROBIAL SOURCE Chemical Properties |
storage temp. | 2-8°C | solubility | Soluble in DMSO | form | powder | color | white | LogP | 3.048 (est) |
Hazard Codes | T | Risk Statements | 23/24/25 | Safety Statements | 22-36/37/39-45 | RIDADR | 2811 | HazardClass | 6.1(a) | PackingGroup | I | HS Code | 2934999090 |
| ENNIATIN FROM MICROBIAL SOURCE Usage And Synthesis |
Uses | Enniatin complex is a complex mixture of Fusarium produced depsipeptide ionophores.This compound can be used to control contamination in fermentation of gaseous substrates. | Uses | Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumour action have received more focus. | Biological Activity | enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from fusarium species of fungis, also they have been isolated from other genera, such as verticillium and halosarpheia [1]. they have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic [1]. | in vitro | fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (icam-1) by activated macrophages, inhibited the production of the proinflammatory cytokines il-1, tnfα and il-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. fusafungine also inhibited t-cell activation and proliferation, and the synthesis of ifn-γ by activated t cells [2]. exposure 8 h to enniatins at nanomolar concentrations significantly stimulated cell proliferation. at low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. in the fluorescence-activated cell sorting analysis, enniatins induced cell cycle arrest in the g0/g1 phase. in human cancer cells, elevated enn concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities [3]. enniatin easily incorporated into the cell membrane in which it formed cation-selective pores [4]. | Purification Methods | It is a cyclic peptidic ester antibiotic which is recrystallised from EtOH/water but is deactivated in alkaline solution. [Ovchinnikov & Ivanov in The Proteins (Neurath and Hill eds) Academic Press, NY, Vol V pp. 365 and 516 1982, Tomeda et al. J Antibiot 45 1626 1992.] | references | [1] sy-cordero a a, pearce c j, oberlies n h. revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[j]. the journal of antibiotics, 2012, 65(11): 541-549. [2] german-fattal m. fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[j]. clinical drug investigation, 2001, 21(9): 653-670. [3] dornetshuber r, heffeter p, kamyar m r, et al. enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[j]. chemical research in toxicology, 2007, 20(3): 465-473. [4] kamyar m, rawnduzi p, studenik c r, et al. investigation of the electrophysiological properties of enniatins[j]. archives of biochemistry and biophysics, 2004, 429(2): 215-223. |
| ENNIATIN FROM MICROBIAL SOURCE Preparation Products And Raw materials |
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