| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:DiMethisoquin Hydrochloride
CAS:2773-92-4
Package:10g,1g,2.5g
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| Company Name: |
Sinopharm Chemical Reagent Co,Ltd.
|
| Tel: |
86-21-63210123 |
| Email: |
sj_scrc@sinopharm.com |
| Products Intro: |
Product Name:Dimethisoquin Hydrochloride (2 g)
CAS:2773-92-4
Package:2 g
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| | DIMETHISOQUIN HYDROCHLORIDE (2 G) Basic information |
| Product Name: | DIMETHISOQUIN HYDROCHLORIDE (2 G) | | Synonyms: | DIMETHISOQUIN HYDROCHLORIDE (2 G);1-(beta-dimethylaminoethoxy)-3-n-butylisoquinolinehydrochloride;1-(beta-dimethylaminoethoxy)-3-n-butylisoquinolinemonohydrochloride;2-((3-butyl-1-isoquinolinyl)oxy)-n,n-dimethyl-ethanaminmonohydrochloride;3-butyl-1-(2-(dimethylamino)ethoxy)isoquinolinehydrochloride;3-butyl-1-(2-(dimethylamino)ethoxy)-isoquinolinhydrochloride;chinisocainehydrochloride;dimethisoquinhydrochloride | | CAS: | 2773-92-4 | | MF: | C17H25ClN2O | | MW: | 308.8462 | | EINECS: | 2204681 | | Product Categories: | | | Mol File: | 2773-92-4.mol |  |
| | DIMETHISOQUIN HYDROCHLORIDE (2 G) Chemical Properties |
| Melting point | 145.5°C | | density | 1.0887 (rough estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| Toxicity | LD50 i.p. in rats: 45-50 mg/kg (Fellows, Macko) |
| | DIMETHISOQUIN HYDROCHLORIDE (2 G) Usage And Synthesis |
| Originator | Quotane,SKF,US,1951 | | Uses | Dimethisoquin Hydrochloride is a local anesthetic. | | Definition | An ointment and lotion containing
dimethisoquin hydrochloride. | | Manufacturing Process | A mixture of 10.0 grams of β-dimethylaminoethanol and 1.9 grams of sodium
in 90 cc of dry xylene was heated at 95°C for 5 hours. To the resulting
solution was added at 30°C, 18 grams of 3-butyl-1-chloroisoquinoline. The
solution, which turned very dark, was heated at 100°-125°C for 3.5 hours.
The mixture was extracted with two 100 cc portions of 2N hydrochloric acid
solution. The acid solution was made strongly alkaline with 40% potassium
hydroxide solution and the oil which separated was taken into ether. The ether
solution was washed with two 100 cc portions of water saturated with sodium
chloride, and then dried over anhydrous sodium sulfate for 3 hours. The
sodium sulfate was removed by filtration and the ether by distillation.
Distillation of the residual oil gave a colorless liquid, BP 155°-157°C/3mm. | | Therapeutic Function | Local anesthetic |
| | DIMETHISOQUIN HYDROCHLORIDE (2 G) Preparation Products And Raw materials |
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