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| | Methoxycarbonyl-L-tert-leucine Chemical Properties |
| Melting point | 1090C | | Boiling point | 320.9±25.0 °C(Predicted) | | density | 1.126±0.06 g/cm3(Predicted) | | vapor pressure | 0Pa at 25℃ | | storage temp. | 2-8°C | | solubility | Soluble in ethyl acetate and methanol. | | pka | 4.46±0.10(Predicted) | | form | powder | | Water Solubility | 26.4g/L at 20℃ | | InChI | InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1 | | InChIKey | NWPRXAIYBULIEI-RXMQYKEDSA-N | | SMILES | C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O | | LogP | 0.832 at 21℃ |
| | Methoxycarbonyl-L-tert-leucine Usage And Synthesis |
| Description | Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.
| | References | Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
https://www.alfa.com/en/search/?q=14328-63-3
| | Chemical Properties | White Solid | | Uses | The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach. | | Flammability and Explosibility | Not classified |
| | Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials |
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