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BOC Sciences
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| Products Intro: |
Product Name:Nocardamine
CAS:26605-16-3
Purity:>=95% Remarks:Nocardamine, derived from Nocardia sp., has anti-mycobacterium activity.
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| | NOCARDAMINE Basic information |
| Product Name: | NOCARDAMINE | | Synonyms: | NOCARDAMINE;PROFERRIOXAMIN E;deferrioxamine E;1,12,23-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone;6,17,28-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexaone;Desferri-ferrioxamine E;Desferrioxamine E;Nocardamin | | CAS: | 26605-16-3 | | MF: | C27H48N6O9 | | MW: | 600.7 | | EINECS: | | | Product Categories: | | | Mol File: | 26605-16-3.mol |  |
| | NOCARDAMINE Chemical Properties |
| Melting point | 192-195° | | density | 1.162±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (5 mg/ml) | | form | solid | | pka | 8?+-.0.20(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | NOCARDAMINE Usage And Synthesis |
| Description | Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 μM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells. | | Uses | Nocardamine is a cyclic siderophore. | | Definition | ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity. | | storage | +4°C | | References | Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741
Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34
Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49
Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654
Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292 |
| | NOCARDAMINE Preparation Products And Raw materials |
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