| Company Name: |
Hubei Chuchang Chemical Co., Ltd Gold
|
| Tel: |
15623560702 |
| Email: |
Joy.Ren@aliyun.com |
| Products Intro: |
Product Name:BI-2865
CAS:2937327-93-8
Purity:98%+ HNMR HPLC Package:10mg/RMB 2500;500mg/g
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd Gold
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:BI-2865
CAS:2937327-93-8
Purity:98%+ HPLC Package:10mg;500mg;1g;5g;10ASSAYS
|
| Company Name: |
Changzhou Borl Biotechnology Co.,LTD Gold
|
| Tel: |
13606124132;13656121842 |
| Email: |
luyan0021@163.com |
| Products Intro: |
Product Name:BI-2865
CAS:2937327-93-8
Purity:98% Package:1g
|
BI-2865 manufacturers
- BI-2865
-
- $0.00 / 10mg
-
2024-06-07
- CAS:2937327-93-8
- Min. Order: 5mg
- Purity: 98%+ HPLC HNMR
- Supply Ability: 20g
|
| | BI-2865 Basic information |
| | BI-2865 Chemical Properties |
| Boiling point | 708.7±70.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 9.35±0.40(Predicted) |
| | BI-2865 Usage And Synthesis |
| Description | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signaling and proliferation was restricted to cancer cells harboring mutant KRAS, and drug treatment suppressed KRAS mutant tumor growth in mice without having a detrimental effect on animal weight. | | Biological Activity | BI-2865 is a non-covalent pan-KRAS inhibitor that binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with Kd values of 6.9 nM, 4.5 nM, 32 nM, 26 nM, and 4.3 nM, respectively. It can be used in studies related to KRAS mutant tumors.
| | in vitro |
BI-2865 is a derivative with a prolinol substituent and a pyrimidine linker. BI-2865 has direct ionic interaction with E62 and a water-mediated hydrogen bond network with the side chain of R68 and the main chain carbonyl of Q61.
BI-2865 (5 days) inhibits the proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells in the presence of IL-13, with a mean IC50 of roughly 140?nM.
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| | BI-2865 Preparation Products And Raw materials |
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