- Perfluorooctyl iodide
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- $100.00 / 1KG
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2023-12-26
- CAS:507-63-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- Perfluorooctyl iodide
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- $0.00 / 25KG
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2023-04-29
- CAS:507-63-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000
- Perfluorooctyl iodide
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- $25.60 / 1KG
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2023-03-06
- CAS:507-63-1
- Min. Order: 1KG
- Purity: 96%
- Supply Ability: 5000kg
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| | Perfluorooctyl iodide Basic information |
| | Perfluorooctyl iodide Chemical Properties |
| Melting point | 25 °C | | Boiling point | 160-161 °C(lit.) | | density | 2.067 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.329(lit.) | | Fp | 160-161°C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Liquid After Melting | | color | Clear colorless to yellow or light pink | | Sensitive | Light Sensitive | | BRN | 1717141 | | Exposure limits | ACGIH: TWA 0.01 ppm | | InChIKey | KWXGJTSJUKTDQU-UHFFFAOYSA-N | | CAS DataBase Reference | 507-63-1(CAS DataBase Reference) | | NIST Chemistry Reference | Perfluorooctyl iodide(507-63-1) | | EPA Substance Registry System | Octane, 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodo- (507-63-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | UN 2922 | | WGK Germany | 3 | | RTECS | RG9700050 | | F | 8 | | Hazard Note | Harmful | | TSCA | T | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29037800 | | Toxicity | LD50 ivn-mus: 7500 mg/kg MIVRA6 8,320,74 |
| | Perfluorooctyl iodide Usage And Synthesis |
| Chemical Properties | clear light pink liquid after melting | | Uses | Heptadecafluoro-1-iodooctane has been used as monodentate donor to investigate anion receptor complexes of mono-, bi- and tridentate donors with a variety of anions in the gas phase using both experimental and theoretical approaches. | | Uses | Perfluorooctyl Iodide is a perfluoroalkyl iodide used in organocatalysis via substrate activation by halogen bonding. Perfluorooctyl Iodide is a potential candidate substitute for banned Halon fire extinguishers. | | Reactivity Profile |
1H,1H,2H,2H-1Iodide-Perfluorodecane was synthesized using perfluorooctyl iodide and ethylene as materials, then reacted with sodium methoxide /methanol to gain 1H,1H,2H-Heptadecafluorodecene. Influence factors such as the kinds of solvents, raw material configuration, concentration, and time used in the process of dehydrogen iodide were studied mainly. Optimization was using 1,1,2-Trichloro-1,2,2-trifluoroethane as solvent, sodium methoxide /methanol (2mol/L ), 1H,1H,2H,2H-1Iodide-Perfluorodecane( M1 ): sodium methoxide( M2 ) =1:2, reacted 12 hours, the yield of 1H,1H,2H-Heptadecafluorodecene was up to 80%[4-5].
| | Cytotoxicity | Exposure of H295R cells to Perfluorooctyl iodide (PFOI) (<100 μM) and Perfluorooctanoic acid (PFOA) (<100 μM) did not cause significant toxicity within the concentration ranges tested (p > 0.05). However, 125 μM PFOI and PFOA induced significant toxicity in H295R cells (p < 0.05). No obvious morphological alterations were observed in the cells treated with PFOI or PFOA at levels lower than 100 μM upon microscopic examination[1]. | | Biochem/physiol Actions |
Levels of aldosterone production, cortisol, and 17β-estradiol were elevated significantly, and the level of testosterone generation decreased upon treatment with 100 μM PFOI. Similar to the effect induced by forskolin (AC activator), expression of all 10 genes involved in synthesizing steroid hormones was upregulated significantly upon exposure to 100 μM PFOI. PFOA had no effect on steroid hormone production or steroidogenic gene expression, even though it is highly structurally similar to PFOI. Therefore, the terminal -CF2I group in PFOI could be a critical factor for the mediation of steroidogenesis. PFOI increased AC activity and cAMP levels in H295R cells, which implied an underlying mechanism for the disturbance of steroidogenesis. These data suggest that PFOI may act as an AC activator, thereby stimulating steroidogenesis by activating a cAMP signaling pathway[3].
| | Safety Profile | Slightly toxic by intravenous route. When heated to decomposition it emits toxic vapors of Fí and Ií. | | Environmental considerations | Production of perfluorooctyl iodide (PFOI) has great commercial value. PFOI is a potential estrogenic compound. Studies have shown that the concentration of PFOI is relatively higher in the air and soil than the concentrations of the other derivatives of Perfluorinated iodine alkanes (PFIs). In addition, the degradation of PFIs can cause the formation of other Perfluorinated iodine alkanes (PFCs), thereby resulting in environmental behaviors similar to those of FTOHs. Release of PFIs may increase the environmental burden of PFCs[1-2].
| | References |
[1] Chang Wang. "Perfluorooctyl Iodide Stimulates Steroidogenesis in H295R Cells via a Cyclic Adenosine Monophosphate Signaling Pathway." Chemical Research in Toxicology 28 5 (2015): 848–854.
[2] WangYichen. "Estrogen-like response of perfluorooctyl iodide in male medaka (Oryzias latipes) based on hepatic vitellogenin induction." Environmental Toxicology 28 10 (2013): 571–8.
[3] Chang Wang. “Perfluorooctyl Iodide Stimulates Steroidogenesis in H295R Cells via a Cyclic Adenosine Monophosphate Signaling Pathway.” Chemical Research in Toxicology 28 5 (2015): 848–854.
[4] Maria Lumbierres, Adelina Vallribera, Marcial Moreno-Ma?as. “Addition of perfluorooctyl iodide to alkenes. Catalysis by triphenylphosphane.” Tetrahedron 58 20 (2002): Pages 4061-4065.
[5] X. Wang, Ai Fu, G. Chang. “Study on Preparation of 1H,1H,2H-Heptadecafluorodecene.” Advanced Materials Research 19 1 (2013): 2332–2335.
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| | Perfluorooctyl iodide Preparation Products And Raw materials |
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