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| 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Basic information |
| 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Chemical Properties |
storage temp. | Inert atmosphere,2-8°C | solubility | DMSO: 20 mg/mL, soluble | form | solid | color | white |
WGK Germany | 3 | RTECS | TM6241000 |
| 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Usage And Synthesis |
Uses | SKF-89976A is a GABA transporters (GATs) type 1 inhibitor. | Biological Activity | A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo . | storage | +4°C (desiccate) |
| 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Preparation Products And Raw materials |
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