甲硫氨酸脑啡肽酰胺
| 中文名称 | 甲硫氨酸脑啡肽酰胺 |
|---|---|
| 中文同义词 | 甲硫氨酸脑啡肽酰胺;受体激动剂多肽MET-ENKEPHALIN, AMIDE;脑啡肽[MET5]-ENKEPHALIN, AMIDE;601513-1 |
| 英文名称 | Met-enkephalinamide |
| 英文同义词 | 5-Methionine-enkephalin amide;L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-;Lacosamide Impurity 61 |
| CAS号 | 60117-17-1 |
| 分子式 | C27H36N6O6S |
| 分子量 | 572.68 |
| EINECS号 | |
| 相关类别 | 目录肽 |
| Mol文件 | 60117-17-1.mol |
| 结构式 |  |
甲硫氨酸脑啡肽酰胺 性质
| 熔点 | 142-145 °C |
|---|---|
| 沸点 | 1066.7±65.0 °C(Predicted) |
| 密度 | 1.303±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.97±0.15(Predicted) |
[Met5]-Enkephalin, amide 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。
δ and ζ opioid receptor
[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine.