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PR-619

PR-619 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:2645-32-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:PR-619
CAS:2645-32-1
Purity:99% Package:5KG;5USD
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:PR-619
CAS:2645-32-1
Purity:98% Package:Package as requetsed
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PR-619;PR 619;2,6-Diamino-3,5-dithiocyanopyridine;PR619
CAS:2645-32-1
Purity:100.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:PR-619
CAS:2645-32-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

PR-619 manufacturers

  • PR-619
  • PR-619 pictures
  • $5.00 / 5KG
  • 2019-09-04
  • CAS:2645-32-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1ton
PR-619 Basic information
Product Name:PR-619
Synonyms:PR-619;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester;2,6-Diamino-3,5-dithiocyanopyridine PR 619;PR 619 2,6-Diamino-3,5-dithiocyanopyridine;2,6-Diaminopyridine-3,5-bis(thiocyanate);PR-619;PR619
CAS:2645-32-1
MF:C7H5N5S2
MW:223.28
EINECS:200-256-5
Product Categories:Inhibitors
Mol File:2645-32-1.mol
PR-619 Structure
PR-619 Chemical Properties
Melting point 210℃
Boiling point 406.0±45.0 °C(Predicted)
density 1.61±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble5mg/mL (clear solution)
pka-0.19±0.50(Predicted)
form powder
color white to beige
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41-43
Safety Statements 26-36/37/39
WGK Germany 3
MSDS Information
PR-619 Usage And Synthesis
DescriptionPR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become unregulated in cell lysates and will act quickly to deubiquitinate proteins of interest during cell lysis. To preserve maximum amounts of ubiquitinated protein, include PR-619 (50-100 μM) in lysis buffers. PR-619 is also useful for interrogating the role of DUBs in intact cell systems2, and treatment of cells results in an overall accumulation of ubiquitinated proteins and many other phenotypes.
UsesPR-619 has been used:
  • as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
  • as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
  • in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

UsesPR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines an d bisthiazolopyridines.
Biochem/physiol ActionsPR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.
storageStore at -20°C
References1) Altun?et al. (2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes; Chem. Biol.,?18?1401 2) Seiberlich?et al. (2012),?The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases; Biochim. Biophys. Acta,?1823?2057
PR-619 Preparation Products And Raw materials
Tag:PR-619(2645-32-1) Related Product Information
Ko 143 TYRPHOSTIN AG 1296 S-Trityl-L-cysteine (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Bortezomib Degrasyn (WP1130) PYR 41 MG-132 P-5091 P 22077