| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Etomidoline;Etomidoline
CAS:21590-92-1
Purity:98% Package:5 mg
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| | etomidoline Basic information |
| Product Name: | etomidoline | | Synonyms: | etomidoline;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-;Amidoline;K 2680;Nonspa;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);Smedolin;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one | | CAS: | 21590-92-1 | | MF: | C23H29N3O2 | | MW: | 379.5 | | EINECS: | 2444639 | | Product Categories: | | | Mol File: | 21590-92-1.mol |  |
| | etomidoline Chemical Properties |
| Melting point | 106-107° | | Boiling point | 507.34°C (rough estimate) | | density | 1.1315 (rough estimate) | | refractive index | 1.6500 (estimate) | | pka | 8.75±0.10(Predicted) |
| Toxicity | LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971) |
| | etomidoline Usage And Synthesis |
| Originator | Smedolin,Yamanouchi,Japan,1976 | | Definition | ChEBI: Etomidoline is an organic molecular entity. | | Manufacturing Process | 31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol)
are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution
5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added
and the resulted mixture is heated at 70°C for 1 hour, and then poured into
an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-
isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to
104°C) is obtained as a byproduct with the above compound. This latter
compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline. | | Therapeutic Function | Muscle relaxant |
| | etomidoline Preparation Products And Raw materials |
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