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| | 2-Hydroxy-3-trifluoromethylpyridine Basic information |
| | 2-Hydroxy-3-trifluoromethylpyridine Chemical Properties |
| Melting point | 150-153°C | | Boiling point | 223.7±40.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | 9.67±0.10(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11) | | InChIKey | JHDCDEHVUADNKQ-UHFFFAOYSA-N | | SMILES | C1(=O)NC=CC=C1C(F)(F)F | | LogP | 0.71 at 25℃ | | CAS DataBase Reference | 22245-83-6(CAS DataBase Reference) |
| | 2-Hydroxy-3-trifluoromethylpyridine Usage And Synthesis |
| Description |
2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.
| | Chemical Properties | White powder | | Uses | 2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist . |
| | 2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials |
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