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4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID

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Products Intro: Product Name:4H-thieno[3,2-b]pyrrole-5-carboxylic acid
CAS:39793-31-2
Purity:NLT 98% Package:1G;1KG;100KG
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Products Intro: CAS:39793-31-2
Purity:98% Package:g-Kg
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Products Intro: Product Name:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
CAS:39793-31-2
Purity:98% Package:1kg;1USD
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Products Intro: Product Name:4H-Thieno[3,2-b]pyrrole-5-carboxylic acid
CAS:39793-31-2
Purity:95%+ Package:10mg, 50mg,100MG,250mg,500MG,1G,5G,25G,100G
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Products Intro: Product Name:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
CAS:39793-31-2
Purity:0.98 Package:1kg，2kg，5kg，10kg，25kg

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID manufacturers
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Basic information
Product Name:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
Synonyms:4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE);Thieno[2,3-b]pyrrole-5-carboxylic acid;4H-thieno[2,3-d]pyrrole-5-carboxylic acid;D-Amino Acid Oxidase Inhibitor;4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
CAS:39793-31-2
MF:C7H5NO2S
MW:167.19
EINECS:
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Mol File:39793-31-2.mol
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Structure
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties
Melting point 180 °C
Boiling point 437.4±25.0 °C(Predicted)
density 1.609
storage temp. Sealed in dry,2-8°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
form Beige solid
pka4.36±0.30(Predicted)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 22-26-36/37/39
WGK Germany 3
MSDS Information
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Usage And Synthesis
Synthesis Reference(s)Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053
General DescriptionA cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Tag:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID(39793-31-2) Related Product Information
Ethyl thiazole-5-carboxylate 4-Thiazolecarboxylic acid Thiazole-5-carboxylic acid THIAZOLE-4-CARBOXAMIDE 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate 3-BROMO-4(H)-THIENO[3,2-B]PYRROLE-5-CARBOXYLICACID 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER METHYL 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE ETHYL 2-CHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE ETHYL 3-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID,4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid 97% 4-CARBOXYMETHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID ETHYL 3-CHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+% 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID METHYL 4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID