Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:8-M-PDOT;8-Methoxy-2-propionaMidotetralin CAS:134865-70-6 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
EMMX Biotechnology LLC
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Tel: |
888-539-0666 |
Email: |
info@emmx.com |
Products Intro: |
Product Name:8-M-PDOT CAS:134865-70-6 Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| 8-M-PDOT Basic information |
Product Name: | 8-M-PDOT | Synonyms: | 8-METHOXY-2-PROPIONAMIDOTETRALIN;8-M-PDOT;AH 002;8 M PDOT,8MPDOT;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)- | CAS: | 134865-70-6 | MF: | C14H19NO2 | MW: | 233.31 | EINECS: | | Product Categories: | | Mol File: | 134865-70-6.mol | |
| 8-M-PDOT Chemical Properties |
Boiling point | 447.8±45.0 °C(Predicted) | density | 1.09±0.1 g/cm3(Predicted) | storage temp. | Store at RT | solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO | form | Powder | pka | 15.87±0.20(Predicted) |
| 8-M-PDOT Usage And Synthesis |
Description | 8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease. | Uses | AH 002 is a selective melatonin receptor agonist. | Biological Activity | Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively. |
| 8-M-PDOT Preparation Products And Raw materials |
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