| Company Name: |
ATK CHEMICAL COMPANY LIMITED
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3429815786 13301662590 |
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sales@atkchemical.com |
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CAS:289-06-5
Purity:98% Package:1G,5G,100G,500g,1kg
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| Company Name: |
JinOu Biomedical (Nanjing) Co., Ltd.
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13000000000 |
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Product Name:1,3,4-Thiadiazole
CAS:289-06-5
Purity:99% HPLC Package:100G;1KG;100KG
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 15221909166 |
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product02@bidepharm.com |
| Products Intro: |
Product Name:Thiadiazole
CAS:289-06-5
Purity:97% Package:100mg;250mg;1g; Remarks:BD153800
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| | 1,3,4-Thiadiazole Basic information |
| | 1,3,4-Thiadiazole Chemical Properties |
| Melting point | 42.5°C | | Boiling point | 204°C | | density | 1.299 (estimate) | | refractive index | 1.5300 (estimate) | | form | solid | | pka | -0.33±0.10(Predicted) |
| | 1,3,4-Thiadiazole Usage And Synthesis |
| Description | 1,3,4-Thiadiazole is a five-membered, aromatic, weakly basic, planer, electron-deficient, conjugated heterocyclic ring system comprised of two carbon atoms, one sulfur atom, and two pyridine-like nitrogen atoms present at the 3- and 4-positions of the ring. The dipole moment (3.25 D) for 1,3,4-thiadiazole suggests that it is a polar symmetric molecule with pseudo-aromatic character. The carbon atoms at the 2- and 5-positions are electron deficient because of the inductive effect of nitrogen and sulfur and thus they are inert toward electrophilic substitution but reactive toward nucleophilic attack. | | Uses | 1,3,4-Thiadiazole, a bioisostere of the thiazole ring, has been used in the synthesis of cephalosporine and cefazedone, which are used as antibiotics. Megazole is another 1,3,4-thiadiazole-based drug, widely used in the treatment of African trypanosomes, also known as sleeping sickness. Azetepa, a phosphoruscontaining drug, has been used for the treatment of cancer. Tebtheuron is known as a broad-spectrum herbicide and is used to control a variety of weeds and herbaceous and woody plants. Numerous thiadiazole derivatives are patented as bactericides, insecticides, and fungicides. | | Definition | ChEBI: 1,3,4-thiadiazole is a thiadiazole. | | Chemical Reactivity | Atomic charges have been calculated by the DFT method. The maximum charge was found at the S atom (0.818) and thus it is the favorite position for soft nucleophilic attack. The atomic charge on each carbon is ?0.3275. Because of the presence of the two pyridine-like nitrogen atoms in the ring, which make the C2 - and C5 -positions electronically poor, nucleophilic substitution of the leaving groups present at either the C2 - or C5 -position becomes highly facile. However, the atomic charge on N3 and N4 (?0.0308) makes them preferential sites for electrophilic attack and readily N-alkylated or N-acylated. In strongly basic conditions the thiadiazole ring leads to ring fission. | | Biological Activity | Anti-inflammatory,antivira and antimicrobial. |
| | 1,3,4-Thiadiazole Preparation Products And Raw materials |
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