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| | ZK 200775 Basic information |
| Product Name: | ZK 200775 | | Synonyms: | ZK 200775;[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonicacid;Fanapanel;MPQX;7-Morpholino-2,3-dioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxalin-1-ylmethylphosphonic acid;[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate;P-[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid;[[3,4-DIHYDRO-7-(4-MORPHOLINYL)-2,3-DIOXO-6-(TRIFLUOROMETHYL)-1(2H)-QUINOXALINYL]METHYL]PHOSPHONIC ACID | | CAS: | 161605-73-8 | | MF: | C14H15F3N3O6P | | MW: | 409.25 | | EINECS: | | | Product Categories: | | | Mol File: | 161605-73-8.mol |  |
| | ZK 200775 Chemical Properties |
| density | 1.615±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO: ≥20mg/mL | | pka | 2.09±0.10(Predicted) | | form | powder | | color | off-white to light brown |
| WGK Germany | 3 | | HS Code | 2934999090 |
| | ZK 200775 Usage And Synthesis |
| Uses | ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia. | | Biological Activity | Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo . | | storage | Desiccate at +4°C |
| | ZK 200775 Preparation Products And Raw materials |
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