|
|
| | oxyfenamate Basic information |
| Product Name: | oxyfenamate | | Synonyms: | Al-0361;Listica;NSC-108034;P-301;(2-hydroxy-2-phenylbutyl) carbamate;(2-hydroxy-2-phenyl-butyl) carbamate;carbamic acid (2-hydroxy-2-phenyl-butyl) ester;oxyfenamate | | CAS: | 50-19-1 | | MF: | C11H15NO3 | | MW: | 209.243 | | EINECS: | 2000175 | | Product Categories: | | | Mol File: | 50-19-1.mol |  |
| | oxyfenamate Chemical Properties |
| Melting point | 55-56.5° | | Boiling point | 348.6°C (rough estimate) | | density | 1.1547 (rough estimate) | | refractive index | 1.5080 (estimate) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| Toxicity | LD50 orally in mice: 830 mg/kg (Bastian, Clements) |
| | oxyfenamate Usage And Synthesis |
| Originator | Listica,Armour,US,1961 | | Uses | Tranquilizer (minor). | | Definition | ChEBI: Oxyfenamate is an alkylbenzene. | | Manufacturing Process | 2-Phenyl-2-hydroxy-butyl carbamate was prepared by the following method:
49.81 g of 2-phenyl-1,2-butanediol and 25.01 g of pyridine were dissolved in
500 ml of benzene and cooled to 5°C. 34.01 g of ethyl chloroformate was
added over a period of 36 hour at 4°C to 8°C. The reaction mixture was
warmed to room temperature and stirred for 2 hours and then extracted with
100 cc each of the following:
Water, 15% hydrochloric acid, 10% sodium bicarbonate and finally water. The
solvent was stripped off. The residual oil was mixed with 300 ml of 28%
aqueous ammonia for 1 hour. The ammonia and water were vacuum distilled
at a temperature of 40°C or less. Then 300 cc of carbon tetrachloride was
added and the solution dried with sodium sulfate. The solution was cooled at
0°C and then filtered. The crystals were washed with cold carbon tetrachloride
and vacuum dried. The yield was 57 g of dried product having a melting point
of 55°C to 56.5°C. | | Therapeutic Function | Tranquilizer |
| | oxyfenamate Preparation Products And Raw materials |
|