ChemicalBook >> Articles Category List >> Organic reagents

Synthesis Method of N,N-dimethylacetoacetamide

Jan 5，2022

N,N-dimethylacetoacetamide is a clear, colorless to yellow liquid used as a general purpose, low color generating co-promoter for many unsaturated polyester (FRP) resin formulations. It is also used in the production of low VOC unsaturated polyester (FRP) systems for coatings and as an intermediate for the production of insecticides. N,N-dimethylacetoacetamide (DMAAm) is a β-dicarbonyl compound used as an industrial intermediate.

Synthesis Method

3.jpg

Dissolve dimethylamine (5.00 ml, 2.00 M, 10.0 mmol, 2.0 eq.) in toluene (15 ml).

Add diketene acetone adduct (0.670 ml, 5.00 mmol, 1.0 eq.) to the solution dropwise over a period of 5 minutes.

Stir the reaction at room temperature for 15 minutes.

Stir the mixture under reflux for 12 hours.

Cool the mixture to room temperature and remove the solvent in vacuo.

Purify the crude product by FC (EtOAc) to obtain N,N-dimethyl-3-oxobutanamide.

  • Related articles
  • Related Qustion
See also

Hydroxyethyl cellulose (HEC) is a nonionic, water-soluble polymer. It is a white, free-flowing granular powder and is made by reacting ethylene oxide with alkali-cellulose. HEC has uses in the cosmetics and personal care industries as a gel....

Jan 5，2022Surfactant

Polyvinylpyrrolidone did not irritate or induce sensitization when applied to the skin of volunteers, and was not irritant to the eyes of rabbits. It was of low acute toxicity when administered by the intravenous route in humans or by the o....

Jan 5，2022API

N,N-Dimethylacetoacetamide manufacturers