What is 2,5-dimercapto-1,3,4-thiadiazol?

2,5-dimercapto-1,3,4-thiadiazol (BISMUTHIOL; DMTD;DMTZ; 2, 5-dimercapto-1, 3,4-thiadiazol; 2,5-Dimercapto-1, 3,4-Thiadiazole, Oil Damped; 2, 5-Dimereapto-1, 3,4-Thiadiazole; BismuthiolI 2, 5-Dimercapto-1,3,4-Thiadiaz-; 2,5-Dimercapto-1,3 ,4-thiadiazole, 98+%)[1] is an important chemical compounds with the nitrogen and sulfur atoms in its molecular structure. It is well known that various derivatives of 2,5-dimercapto-1,3,4-thiadiazole (hereinafter sometimes referred to as DMTD) are useful lubricant additives for the inhibition of copper activity (corrosion or staining) and "lead paint' deposition. Many patents have issued on additives containing DMTD nuclei. Because of the insolubility of DMTD itself in mineral oils of the type useful as lubricant bases, further reaction of some kind or another is necessary in order to produce oil-dispersible products. It is of interest to maximize the amount of DMTD or similar moieties in these oil-soluble materials, so as to obtain optimum effect thereof when the materials are incorporated in lubricants. Many researchers have done some studies about the 2,5-dimercapto -1,3,4-thiadiazole derivatives. Arakelian et al.[2] have explored to provide compositions convenient for the incorporation of DMTD or similar moieties into oil-soluble or oil-dispersible compositions and provide a method for the preparation of compositions containing relatively large amounts of DMTD moieties, for use in suppressing copper activity and "lead paint' depositions in lubricants.

At the same time, Weerasak Samee et al.[3] have also studies that A series of 2,5-dimercapto- 1,3,4- thiadiazole derivatives (compounds 1 to 10) were prepared by nucleophilic substitution reaction between 2,5-dimercapto-1,3,4-thiadiazole and chloroheterocyclic compounds in methanol and in the presence of potassium carbonate (compounds 1 to 5 and 8) or metallic sodium (compounds 6, 7, 9 and 10) at room temperature. They also provided the synthesis of novel 2,5-dimercapto-1,3,4-thiadiazole derivatives with alkyl heterocyclic or heterocyclic moieties.

In addition, 2,5-Dimercapto-1,3,4-thiadiazol (DMTD) can bind on the surface of a gold electrode through the strong gold–sulfur interaction. It was utilized successfully to detect the concentration of Cu(Ⅱ) ions in tap water samples.[4]

References

[1] https://www.chemicalbook.com/ProductChemicalPropertiesCB7268117_EN.htm
[2] Arakelian A N, Davis K E. 2, 5-Dimercapto-1, 3, 4-thiadiazole derivatives and lubricants containing them: U.S. Patent 4,246,126[P]. 1981-1-20.
[3] Samee W, Vajragupta O. Antifungal, cytotoxic activities and docking studies of 2, 5-dimercapto-1, 3, 4-thiadiazole derivatives[J]. African journal of pharmacy and pharmacology, 2011, 5(4): 477-485.
[4] Jiang Y N, Luo H Q, Li N B. Determination of copper (II) by anodic stripping voltammetry at a 2, 5-dimercapto-1, 3, 4-thiadiazol self-assembled monolayer-based gold electrode[J]. Analytical sciences, 2006, 22(8): 1079-1083.