Chlorambucil

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Carcinogenicity, Category 1B

H301 Toxic if swalloed

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

H350 May cause cancer

P201 Obtain special instructions before use.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P405 Store locked up.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

SYMPTOMS: Symptoms of exposure to this compound include leukemia, dyspnea, cough, interstitial fibrosis and menstrual cycle changes or disorders. It may cause keratitis epithelialis in association with exfoliative dermatitis and reversible pseudotumor cerebri with papilledema. It may also cause vomiting, lethargy and unconsciousness with grand mal seizures. Other symptoms include convulsions, infertility, reversible and permanent sterility, lymphopenia, neutropenia, bone marrow suppression, gastrointestinal disturbances such as nausea, diarrhea and oral ulceration, hepatotoxicity, jaundice, drug fever, skin hypersensitivity, peripheral neuropathy, sterile cystitis, fibrosis, vasculitis and depletion of primordial follicles, skin rash, bleeding, unusual lumps, agitated behavior and ataxia. It may cause hyperuricemia, which may lead to acute renal failure, reversible pancytopenia, sideroblastic anemia and myeloblastic leukemia. Exposure may cause erythroleukemia, reticulum-cell sarcoma, lymphosarcoma, myelosuppression, viral, fungal and bacterial infections, chromosomal damage and oligospermia, azoospermia and disappearance of testicular germinal cells in males. It may cause irreversible bone marrow depression, central nervous excitation and jerky movements. It may also cause thrombocytopenia, leucopenia and hemorrhage of the skin and mucous membranes. Other symptoms of exposure include coma, irritation to the skin and mucous membranes, lymphocytopenia, cutaneous pigmentation, adrenal cortical insufficiency and neurotoxicity. It may cause amenorrhea and dermatitis. When administered to a pregnant woman, the offspring may develop unilateral renal agenesis. It may be injurious to the developing retina. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin and mucous membranes. It is rapidly and completely absorbed from the gastrointestinal tract. When heated to decomposition it emits toxic fumes of chlorine and nitrogen oxides. (NTP, 1992)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials.

Literature sources indicate that this chemical is nonflammable. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

PRECAUTIONS FOR ANTINEOPLASTIC AGENTS:/ If hazardous drugs are routinely prepared or administered in carpeted areas, special equipment is necessary to remove the spill. Absorbent powder should be substituted for pads or sheets and left in place on the spill for the time recommended by the manufacturer. The powder should then be picked up with a small vacuum unit reserved for hazardous drug cleanup. The carpet should then be cleaned according to usual procedures. The vacuum bag should be removed and discarded or cleaned, and the exterior of the vacuum cleaner should be washed with detergent and rinsed before being covered and stored. The contaminated powder should be discarded into a sealable plastic bag and segregated with other contaminated waste materials. Alternatively, inexpensive wet or dry vacuum units may be purchased for this express use and used with appropriate cleaners. All such units are contaminated, once used, and must be cleaned, stored, and ultimately discarded /properly/ ... The circumstances and handling of spills should be documented. Health-care personnel exposed during spill management should also complete an incident report or exposure form. Antineoplastic agents

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in a refrigerator, 2 to 8 deg C (36 to 46 deg F).

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Sensitive to light and heat.

CHLORAMBUCIL is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds (NTP, 1992).

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When heated to decomposition it emits very toxic fumes of /hydrogen chloride and nitrogen oxides/.

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Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: sufficient. Overall summary evaluation of carcinogenic risk to humans is Group 1: The agent is carcinogenic to humans. From table

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An estimated BCF of 3 was calculated in fish for chlorambucil(SRC), using a log Kow of 1.70(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of chlorambucil is estimated as 11(SRC), using a log Kow of 1.70(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that chlorambucil is expected to have very high mobility in soil. The pKa of chlorambucil is 5.75(1), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2811 (For reference only, please check.)

IMDG: UN2811 (For reference only, please check.)

IATA: UN2811 (For reference only, please check.)

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available