Cyanogen bromide
Product identifier
- Product name: Cyanogen bromide
- CBnumber: CB9853692
- CAS: 506-68-3
- EINECS Number: 208-051-2
- Synonyms: BrCN,cyanic bromide
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Acute toxicity - Category 1, Dermal
Skin corrosion, Sub-category 1B
Acute toxicity - Category 2, Inhalation
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Label elements
Pictogram(s)
- Signal wordDanger
H225 Highly Flammable liquid and vapour
H300 Fatal if swallowed
H310 Fatal in contact with skin
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H330 Fatal if inhaled
H336 May cause drowsiness or dizziness
H351 Suspected of causing cancer
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P320 Specific treatment is urgent (see … on this label).
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P320 Specific treatment is urgent (see ... on this label).
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Cyanogen bromide
- Synonyms: BrCN,cyanic bromide
- CAS: 506-68-3
- EC number: 208-051-2
- MF: CBrN
- MW: 105.92
Description of first aid measures
If inhaledFresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Refer for medical attention . See Notes. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Most important symptoms and effects, both acute and delayed
Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. Vapors are highly irritant and very poisonous. Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects. (EPA, 1998)
Indication of any immediate medical attention and special treatment needed
Cyanokit is indicated for the treatment of known or suspected cyanide poisoning. ... If clinical suspicion of cyanide poisoning is high, Cyanokit should be administered without delay.... Cyanokit (hydroxocobalamin for injection) 5 g is a cyanide antidote package which contains two colorless 250 mL glass vials, each of which contains 2.5 g dark red lyophilized hydroxocobalamin, pH adjusted with hydrochloric acid, two transfer spikes, one IV administration set, one quick use reference guide and one package insert. The action of Cyanokit in the treatment of cyanide poisoning is based on its ability to bind cyanide ions. ...Caution should be exercised when administering other cyanide antidotes simultaneously with Cyanokit, as the safety of co-administration has not been established. If a decision is made to administer another cyanide antidote with Cyanokit, these drugs should not be administered concurrently in the same IV line. Cyanide
Extinguishing media
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use foam, dry chemical, or carbon dioxide. Cool all affected containers with flooding quantities of water. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities of spray and fog.
Specific Hazards Arising from the Chemical
Cyanogen bromide is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Vapors are highly irritating. When material is heated to decomposition, it emits very toxic fumes of cyanide and bromide. Avoid water, acids. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. (EPA, 1998)
Advice for firefighters
In case of fire in the surroundings, use appropriate extinguishing media.
NFPA 704
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
In the event of a spill, sweep up cyanogen bromide, place in an appropriate container, and dispose of properly. Respiratory and appropriate impermeable protective gloves and clothing should be worn while conducting cleanup of this highly toxic substance.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. See Chemical Dangers. Dry. Well closed.Cyanogen bromide can polymerize violently on prolonged storage at ambient temperature. ... /In the laboratory/ Containers of cyanogen bromide should be kept tightly sealed and stored under nitrogen in a secondary container in a refrigerator.
Control parameters
Occupational Exposure limit valuesTLV: 0.3 ppm as STEL
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety goggles, face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use closed system or ventilation.
no data available
Information on basic physicochemical properties
- Physical stateSolution
- ColourWhite
- Odour
Penetrating
- Melting point/freezing point
49-54°C
- Boiling point or initial boiling point and boiling range
61-62°C
- Flammability
Not combustible but forms flammable gas on contact with water or damp air. Gives off irritating or toxic fumes (or gases) in a fire.
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
61.4°C
- Auto-ignition temperature
Not Applicable. Not flammable. (USCG, 1999)
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- SolubilitySoluble in chloroform, dichloromethane, ethanol, diethyl ether, benzene and acetonitrile.
- Partition coefficient n-octanol/water
no data available
- Vapour pressure100 mm Hg ( 22.6 °C)
- Density and/or relative density
1.443
- Relative vapour density
3.65 (vs air)
- Particle characteristics
no data available
Reactivity
Decomposes on heating and on contact with acids. This produces highly toxic and flammable hydrogen cyanide (see ICSC 0492) and corrosive hydrogen bromide (see ICSC 0282). Reacts with strong oxidants. Reacts slowly with water and moisture. This produces hydrogen bromide and hydrogen cyanide. Attacks many metals in the presence of water.
Chemical stability
Cyanogen bromide is moderately endothermic ... & shows evidence of instability.
Possibility of hazardous reactions
NoncombustibleThe vapour is heavier than air.CYANOGEN BROMIDE is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. [EPA, 1998]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).
Conditions to avoid
no data available
Incompatible materials
Reacts with acids, water to release highly toxic hydrogen cyanide.
Hazardous decomposition products
If involved in a fire decomposes to produce toxic gases.
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is severely irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. See Notes. The effects may be delayed. The substance may cause effects on the cellular respiration. This may result in convulsions, unconsciousness and respiratory failure. Medical observation is indicated. Exposure could cause death.
STOT-repeated exposure
no data available
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) length 33-75 mm; Conditions: freshwater, static, 23 deg C, pH 7.6-7.9, hardness 55 mg/L CaCO3; Concentration: 240 ug/L for 96 hr /formulated product
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN1889 (For reference only, please check.)
IMDG: UN1889 (For reference only, please check.)
IATA: UN1889 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CYANOGEN BROMIDE (For reference only, please check.)
IMDG: CYANOGEN BROMIDE (For reference only, please check.)
IATA: CYANOGEN BROMIDE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Sublimes at room temperature.The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.Commercial products are generally solutions in chloroform.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.