Estrone

Carcinogenicity, Category 2

Reproductive toxicity, Category 1A

Reproductive toxicity, Additional category for effects on or via lactation

H225 Highly Flammable liquid and vapour

H351 Suspected of causing cancer

H360 May damage fertility or the unborn child

H362 May cause harm to breast-fed children

H370 Causes damage to organs

P201 Obtain special instructions before use.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P263 Avoid contact during pregnancy/while nursing.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P281 Use personal protective equipment as required.

P311 Call a POISON CENTER or doctor/physician.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P370+P378 In case of fire: Use … for extinction.

P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P263 Avoid contact during pregnancy and while nursing.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

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Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials. ... As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.

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Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high-efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in the original package. Do not store above 25 deg C.

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Stable in air.

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When heated to decomposition it emits acrid smoke and fumes.

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Estrogens, Steroidal: known to be human carcinogens. Estrogens, Steroidal

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AEROBIC: Estrone exhibited approximately 38% mineralization in 33 days using 4 Mile Creek sediment, 56% mineralization in 33 days using Boulder Creek sediment, and up 90% mineralization using South Platte River sediments, Colorado. Sediments were collected downstream of local waste water treatment plants. Upstream sediments exhibited approximately 1, 1, and 1% mineralization, respectively(1). Estrone is biodegraded by sewage bacteria via ring cleavage, ultimately to carbon dioxide through a tricarboxylic acid cycle(2). C14-labeled estrone, present at 0.1 mg/kg, reached 2.0-17.4% mineralization in 21 days using natural German and Austrian soils in microcosm incubations maintained at 20 deg C(3,4). Soil-specific percent 14CO2 evolution values of 5.4, 4.6, 11.1, 2.0, and 17.4 were reported using Metelan (grassland, 3.3% SOC), Koeln (crop field, 0.7% SOC), Halle (crop field, 1.3% SOC), Gumpenstein (crop field, 2.2% SOC), and Hamapil (orchard, 1.5% SOC) soil microcosms, respectively(4).

An estimated BCF of 54 was calculated in fish for estrone(SRC), using a log Kow of 3.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Koc of estrone was reported as 2,000-18,000, using a Chelsea, MI topsoil (total organic carbon 5.45%)(1). Natural estrogens such as estrone are mainly removed from the aqueous phase by adsorption onto solids such as sludge in wastewater or soil in cases of land application(2). Sorption of estrone from CaCl2 solution and artificial urine in pastoral soils from North Island, New Zealand was studied. The log Koc values using Horotiu silt loam (pH 5.4; % OC 8.2; % Sand 34; % Silt 48; % Clay 17), Hamilton clay loam (pH 5.1; % OC 4; % Sand 19; % Silt 51; % Clay 30), and TeKowhai silt loam (pH 5.1; % OC 5; % Sand 9; % Silt 54; % Clay 37) were 2.66 and 2.75, 2.93 and 3.04, and 3.15 and 2.9, respectively(3), corresponding to Koc values of 457 and 562, 851 and 1096, and 1412 and 794, respectively(SRC). According to a classification scheme(4), these Koc values suggest that estrone mobility in soil is moderate to immobile. In soils with a long history of treatment with manure, biosolids, or wastewater, sorption of estrone becomes dependent on soil organic carbon content (SOC). Kd values of 122, 46, 134, 72, and 67 mL/g were reported using Metelan (grassland, SOC 3.3%), Koeln (crop field, 0.7% SOC), Halle (crop field, 1.3% SOC), Gumpenstein (crop field, 2.2% SOC), and Hamapil (orchard, 1.5% SOC) soils in Germany, respectively(5). A Kd of 402 L/kg was reported using activated sludge(6).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available