PYRIDINE-D5

Flammable liquids, Category 2

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

H225 Highly Flammable liquid and vapour

H302 Harmful if swallowed

H312 Harmful in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H332 Harmful if inhaled

H351 Suspected of causing cancer

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P281 Use personal protective equipment as required.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P317 Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P332+P317 If skin irritation occurs: Get medical help.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P235 Store in a well-ventilated place. Keep cool.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aromatic hydrocarbons and related compounds

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Solid streams of water may be ineffective. Use water spray to keep fire-exposed containers cool.

Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. (USCG, 1999)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Personal protection: self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

1. remove all ignition sources. 2. ventilate area of spill or leak. 3. for small quantities, absorb on paper towels, evaporate in safe place (such as fume hood). allow sufficient time for evaporating vapors to completely clear hood ductwork. burn paper in suitable location away from combustible material. 3. large quantities can be collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. pyridine should not be allowed to enter confined space, such as sewer, because of possibility of explosion.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Well closed.OUTSIDE OR DETACHED STORAGE IS PREFERABLE. ISOLATE FROM POWERFUL OXIDIZING MATERIALS AND ACIDS.

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Decomposes on burning. This produces toxic fumes of nitrogen oxides and hydrogen cyanide. The substance is a weak base. Reacts violently with strong oxidants and strong acids.

Mixtures with formamide + iodine + sulfur trioxide are storage hazards, releasing carbon dioxide & sulfuric acid.

Pyridine is a flammable ... liquid.The vapour is heavier than air and may travel along the ground; distant ignition possible.PYRIDINE is a base. Reacts exothermically with acids. During preparation of a complex of pyridine with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of pyridine (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing pyridine in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, pyridine, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in pyridine solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).

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Pyridine reacts violently with chlorosulfonic acid, chromic acid, maleic anhydride, nitric acid, fuming sulfuric acid, perchromates, beta-propiolactone, silver perchlorate, & sulfuric acid.

When pyridine is heated to decomposition, cyanide fumes are released.

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A3: Confirmed animal carcinogen with unknown relevance to humans.

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Results of biodegradability screening tests for pyridine using sewage or activated sludge inocula give mixed results ranging from rapid to no degradation(1-5,7). Although biodegradability is improved in longer tests employing a more vigorous inocula, sometimes the same test gives disparate results(1-4,7). Variations in the particular sewage or activated sludge inoculum would affect test results. One investigator obtained results ranging from 97% degradation in 6 days to no degradation in 30 days in 6 different standard tests(1). After a preincubation step was added to one test in which no degradation was observed in 19 days, degradability increased to 91%(3). However the closed bottle test which employs only a drop of sewage effluent as an inoculum, registered no degradation even with a preincubation step(1,3). Tests that were designed to simulate biological treatment plants resulted in complete and rapid removal of pyridine(1,9). In one test that employed a soil suspension as an inoculum, 100% degradation was obtained in 66-170 days(6). When this test was repeated under anaerobic conditions, degradation was more rapid(6). Complete degradation was obtained in 32-66 days(6). When 2 micromoles/g of pyridine was incubated with a silt loam soil, 11.7% remained after 4 days and none remained after 8 days(8). The biodegradation rate constant for pyridine in water was 0.0033 - 0.018 per hour which corresponds to half-lives of 39-210 hours(10).

The bioconcentration factor in guppies exposed to an unspecified concentration of pyridine over a 2-day incubation period was 88(1). According to a classification scheme(2), this BCF suggests the bioconcentration in aquatic organisms moderate.

The Koc of pyridine is estimated as 50(SRC), using a measured log Kow of 0.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that pyridine is expected to have high mobility in soil. The pKa of pyridine is 5.23(4), which indicates that pyridine will partially exist in the protonated form under acidic conditions and cations adsorb more strongly to soil surfaces than neutral molecules(SRC). The adsorption of pyridine to a basic subsoil (pH 8.15, 0.58% organic carbon) is negligible, while in an acidic subsoil (pH 4.85, O.24% organic carbon), the Freundlich adsorption constant was measured to be 5.78 and the slope 0.679(5). This suggests a cationic adsorption mechanism as pyridine is predominantly in its protonated form. Pyridine adsorbs to colloidal particles of sodium montmorillonite and kaolinite, a process which is attributed to cation exchange and is a function of pH(5). Adsorption is at a minimum at pH 1 and 11 and reaches a maximum at pH 4 for the montmorillonite and pH 5.5 for the kaolinite where the adsorption constants are 60 and 10, respectively(6).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN1282 (For reference only, please check.)

IMDG: UN1282 (For reference only, please check.)

IATA: UN1282 (For reference only, please check.)

ADR/RID: PYRIDINE (For reference only, please check.)

IMDG: PYRIDINE (For reference only, please check.)

IATA: PYRIDINE (For reference only, please check.)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

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no data available