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ChemicalBook >> CAS DataBase List >> Rhein

Rhein

Rhein price.
  • $5 - $2120
  • Product name: Rhein
  • CAS: 478-43-3
  • MF: C15H8O6
  • MW: 284.22
  • EINECS:207-521-4
  • MDL Number:MFCD00009618
  • Synonyms:chrysazin-3-carboxylicacid ;monorhein ;rheicacid ;RHUBARB YELLOW;RHEIN;TIMTEC-BB SBB001152;1,8-DIHYDROXY-9,10-ANTHRAQUINONE-3-CARBOXYLIC ACID;1,8-dihydroxy-3-carboxyanthraquinone
Price61 Properties Safety Information Description
61 prices
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Chemtos
  • Crysdot
  • DC Chemicals
  • JR MediChem
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
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  • 0.5g
  • 1g
  • 5g
  • 10g
  • 25g
  • 50g
  • 100g
  • ManufacturerAK Scientific
  • Product numberC432
  • Product descriptionRhein
  • Packaging1g
  • Price$364
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH60902
  • Product descriptionRhein, 97%
  • Packaging250mg
  • Price$154.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH60902
  • Product descriptionRhein, 97%
  • Packaging1g
  • Price$456
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging25mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging100mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging250mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging1g
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging5g
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging25g
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging100g
  • Price$548
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026593
  • Product descriptionRHEIN 95.00%
  • Packaging100MG
  • Price$739.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026593
  • Product descriptionRHEIN 95.00%
  • Packaging1G
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging100mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging200mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging500mg
  • Price$152
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99157
  • Product descriptionRhein ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific C432 Rhein 1g $364 2021-12-16 Buy
Alfa Aesar H60902 Rhein, 97% 250mg $154.65 2024-03-01 Buy
Alfa Aesar H60902 Rhein, 97% 1g $456 2024-03-01 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 25mg $5 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 100mg $6 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 250mg $9 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 1g $19 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 5g $58 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 25g $188 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 100g $548 2021-12-16 Buy
American Custom Chemicals Corporation API0026593 RHEIN 95.00% 100MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation API0026593 RHEIN 95.00% 1G $1871.1 2021-12-16 Buy
ApexBio Technology N1810 Rhein 100mg $53 2021-12-16 Buy
ApexBio Technology N1810 Rhein 200mg $84 2021-12-16 Buy
ApexBio Technology N1810 Rhein 500mg $152 2021-12-16 Buy
Arctom CFN99157 Rhein ≥98% 20mg $40 2021-12-16 Buy
Next Last

Properties

Melting point :≥300 °C (lit.)
Boiling point :346.72°C (rough estimate)
Density :1.3269 (rough estimate)
refractive index :1.4413 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.17±0.20(Predicted)
color :Yellow to Dark Orange
Water Solubility :<0.1 g/100 mL at 17 ºC
λmax :432nm(MeOH)(lit.)
Merck :14,8176
BRN :2222155
Stability :Hygroscopic
InChIKey :FCDLCPWAQCPTKC-UHFFFAOYSA-N
LogP :4.290 (est)
CAS DataBase Reference :478-43-3(CAS DataBase Reference)
EPA Substance Registry System :2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (478-43-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.

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Suppliers and manufacturers

Wuhan ShuEr Biology Technology Co.,Ltd
Rhein
$20.00 /20kgkg
Rhein CAS:478-43-3
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Rhein
$0.00 /1kg
Rhein CAS:478-43-3
career henan chemical co
Rhein
$1.00 /1KG
Rhein CAS: 478-43-3
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Zheyan Biotech Co., Ltd.
Shaanxi Yikanglong Biotechnology Co., Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Hubei Jusheng Technology Co.,Ltd.