1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE synthesis
- Product Name:1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE
- CAS Number:24085-05-0
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
99-93-4
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Yield:-
Reaction Conditions:
with hydrogenchloride;formaldehyd
Steps:
24 EXAMPLE 24
EXAMPLE 24 To a mixture of 260 cc. of 37% formaldehyde and 1800 cc. of concentrated hydrochloric acid is added 400 g. of p-hydroxyacetophenone at a temperature of about 45°C. The mixture is maintained at 50°C. for two hours, filtered, and washed with water to give 3-chloromethyl-4-hydroxyacetophenone, m.p. 154°C. dec.
References:
SmithKline Corporation US3933913, 1976, A
