1-Bromo-4-propylbenzene synthesis
- Product Name:1-Bromo-4-propylbenzene
- CAS Number:588-93-2
- Molecular formula:C9H11Br
- Molecular Weight:199.09
Yield:588-93-2 90.5%
Reaction Conditions:
with iron(III)-acetylacetonate;magnesium;zinc(II) chloride in tetrahydrofuran at 40 - 60; for 8 h;Inert atmosphere;
Steps:
5 Example 1
General procedure: Under a nitrogen atmosphere, to a two-liter three-necked flask was added 236 g of p-dibromobenzene, 185 g of 1-bromopropane and 1 liter of anhydrous tetrahydrofuran; followed by addition of 204 g of zinc chloride, 36 g of magnesium powder and 18 Grams of acetylacetone iron. The mixture was heated to about 40 °C under stirring, the reaction was initiated after a few minutes, the reaction temperature was controlled at not more than 60 °C for 8 hours. The reaction mixture was then cooled to room temperature and quenched by stirring with 200 ml of water. The tetrahydrofuran solvent was recovered by distillation and the residue was diluted with 500 ml of toluene. The toluene layer was separated and washed twice with 200 ml of saturated brine and dried over anhydrous sodium sulfate Drying, filtration, filtrate recovery of toluene recovery, and then vacuum distillation, collecting at 94-97 °C / 10 mmHg to give 170 g of p-bromopyrophenyl. The yield was 85%.
References:
East China Normal University;East China University of Science and Technology;Zou Gang;Tang Jie;Wang Zhicheng;Luo Tian;Liu Ting;Guan Changwei;Wang Chen CN106278811, 2017, A Location in patent:Paragraph 0035-0047
10342-83-3
216 suppliers
$5.00/5g
588-93-2
254 suppliers
$9.00/5g
2294-43-1
36 suppliers
$256.00/1g
588-93-2
254 suppliers
$9.00/5g
