Bromoxynil synthesis
- Product Name:Bromoxynil
- CAS Number:1689-84-5
- Molecular formula:C7H3Br2NO
- Molecular Weight:276.91
767-00-0
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1689-84-5
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Yield:1689-84-5 99%
Reaction Conditions:
with hydrogenchloride;bromide;bromate in water at 28;Product distribution / selectivity;
Steps:
1
EXAMPLE 1 10 gm of 4-hydroxybenzonitrile (0.084 mol) was taken in a 1 litre two necked round bottomed flask, to it 92 ml of aqueous brominating reagent solution [comprises the bromide and bromate in 2:1 molar ratio with the active (reactive) bromide content 14.57 % (w/v)] (0.167 mol) and 310 ml of water was added. The reaction mixture was stirred vigorously to dissolve 4-hydroxybenzonitrile completely. Then 18 ml of 36% HCl (0.18 mol) was added slowly under stirring over a period of 2h at 28° C. The reaction mixture was allowed to stir for another 2.5 h. The reaction mixture was filtered through Buchner funnel, washed with deionized water, the solid material was allowed to dry at 160mm Hg pressure and then dried in oven at 8O0C. The weight of the dried product was 23.10 gm (99% yield) melting point observed 191°C.
References:
COUNCIL OF SCIENTIFIC &;INDUSTRIAL RESEARCH (An Indian Registered body incorporated under the Registration of Societies Act (Act XXXI of 1860);ADIMURTHY, Subbarayappa;RAMACHANDRAIAH, Gadde;JOSHI, Girdhar;PATIL, Rajendra;GANDHI, Maheshkumar, Ramniklal;SUBBAREDDY, Mallampati;MAITI, Pratyush WO2010/97812, 2010, A1 Location in patent:Page/Page column 9
126747-14-6
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1689-84-5
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25952-74-3
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2315-86-8
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2973-77-5
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1689-84-5
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