2,4-Dichloro-5-methoxypyrimidine synthesis
- Product Name:2,4-Dichloro-5-methoxypyrimidine
- CAS Number:19646-07-2
- Molecular formula:C5H4Cl2N2O
- Molecular Weight:179
6623-81-0
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$6.00/1g
19646-07-2
321 suppliers
$15.00/1g
Yield:19646-07-2 75%
Reaction Conditions:
with N,N-dimethyl-aniline;trichlorophosphate for 2 h;Reflux;
Steps:
Intermediate 2: 2,4-Dichloro- -methoxypyrimidine2,4-Dihydroxy-5-methoxypyrimidine (45g, 0.316mol), phosphorous oxychloride (225mL, 0.88mol), and Ν,Ν-dimethylaniline (45mL, 0.391mol) were heated under reflux for 2h. The mixture was poured onto crushed ice (80 g.), and the product collected in ether. Recrystallisation from light petroleum (b.p: 40-60 °C) gave 2,4- dichloro-5-methoxypyrimidine (43g, 75%).Mass: (ES+) 179 (M+H)+
References:
WO2011/144577,2011,A1 Location in patent:Page/Page column 24
6623-81-0
269 suppliers
$6.00/1g
19646-07-2
321 suppliers
$15.00/1g