2-(4-hydroxyphenyl)propiononitrile synthesis

6synthesis methods

Product Name:2-(4-hydroxyphenyl)propiononitrile
CAS Number:21850-61-3
Molecular formula:C9H9NO
Molecular Weight:147.1739

2628-17-3 Synthesis

2628-17-3
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21850-61-3
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Yield:21850-61-3 73%

Reaction Conditions:

with bis(1,5-cyclooctadiene)nickel ⁽⁰⁾;hydrogen cyanide;(3aR,8aR)-4,4,8,8-tetrakis(3,5-dimethylphenyl)-6-(2-(diphenylphosphino)-6-isopropylphenoxy)-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine in tetrahydrofuran at 20; for 2 h;Inert atmosphere;Schlenk technique;enantioselective reaction;

References:

Falk, Anna;Cavalieri, Alberto;Nichol, Gary S.;Vogt, Dieter;Schmalz, Hans-Günther [Advanced Synthesis and Catalysis,2015,vol. 357,# 14-15,p. 3317 - 3320] Location in patent:supporting information