4-Hydroxystyrene synthesis
- Product Name:4-Hydroxystyrene
- CAS Number:2628-17-3
- Molecular formula:C8H8O
- Molecular Weight:120.15
7400-08-0
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$29.00/10g
2628-17-3
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$6.00/1g
Yield:2628-17-3 97%
Reaction Conditions:
with 4-methoxy-phenol in water;N,N-dimethyl-formamide at 150; for 4 h;Solvent;
Steps:
1-13 Example 12
A stirrer, a thermometer,A 50 ml flask equipped with a reflux condenser was charged with p-hydroxycinnamic acid9.85 g (60 mmol),0.12 g (1 mmol) of p-methoxyphenol as a polymerization inhibitor,And a water content adjusted to a moisture content of 3% by weight as a solvent20 ml of N, N-dimethylformamide was charged,With stirring,Immersed in an oil bath temperature controlled at 150 ° C and heated.After continuing heating for 4 hours,The reaction solution was analyzed by the above-mentioned method using HPLC, and it was confirmed that the raw material p-hydroxycinnamic acid had disappeared. Subsequently, the reaction solution was diluted with 50 g of toluene, 50 g of water was added, and the mixture was thoroughly stirred, and then the aqueous layer and the oil layer were separated. The oil layer was further washed with 25 g of water, and the aqueous layer and the oil layer were separated. The solvent was distilled off from the oil layer under reduced pressure to obtain a yellow-brown solid 6.97 g (97% of the theoretical yield). When chemical purity was analyzed by HPLC using the above-mentioned method, the chemical purity of p-hydroxystyrene was 96.2% (area percentage).
References:
TORAY FINE CHEMICALS COMPANY LIMITED;ISHIKAWA, MICHIYA;NAKATANI, JIRO JP6008201, 2016, B2 Location in patent:Paragraph 0057-0066
2156-04-9
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2628-17-3
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2628-16-2
377 suppliers
$7.00/1g
2628-17-3
229 suppliers
$6.00/1g