ChemicalBook CAS DataBase List 2-Methylindoline

2-Methylindoline synthesis

12synthesis methods

Product Name:2-Methylindoline
CAS Number:6872-06-6
Molecular formula:C9H11N
Molecular Weight:133.19

1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone

131880-76-7
8 suppliers
$75.00/100mg

1H-Indole, 1-ethyl-2,3-dihydro-2-methyl-

54813-73-9
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6872-06-6
266 suppliers
$5.00/5g

Yield:6872-06-6 90% ，54813-73-9 10%

Reaction Conditions:

with triethyl borane;Triethoxysilane;sodium hydroxide in hexane at 80; for 6 h;Inert atmosphere;Sealed tube;Reagent/catalyst;Solvent;

Steps:

19 Example 19

Under argon atmosphere, NaOH and triethyl boron were first stirred at room temperature to form a clear clear solution at a concentration of 1 M / L;Subsequently, 10 mol (2 mol%) of the above-mentioned triethylboron solution, 5 mmol of amide substrate, 15 mmol of silane, 2 mL of solventInto a 10 mL sealed tube and placed in an oil bath at 80 ° C for 6 hours with heating. The reaction was completed and the reaction was exposed to air quenching, followed byThe yield was determined by column chromatography and gas chromatography and a pure product was obtained. When using polymethylhydrogensiloxane (PMHS) andTetrahydrofuran as silane and solvent, respectively, the yield of products A, B were: 72%, 11%; when the use of triethoxysilaneThe yield of the products A and B is 90% and 10%, respectively, when the alkyl and n-hexane are used as silane and solvent, respectively.

References:

CN107235845,2017,A Location in patent:Paragraph 0090; 0091; 0092; 0093

1516-96-7 Synthesis