3,4-Dichlorobenzoyl chloride synthesis

Yield:3024-72-4 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 12 h;

Steps:

General procedure A (Synthesis of aroyl chloride from aroyl acid):
To a solution of aroyl acid (1.0eq) in CH₂Cl₂ was added oxalyl dichloride (1.1eq) and DMF (2-5 drops) at 0°C. The mixture was allowed to stir at room temperature for 2-12h. Then the mixture was concentrated to give compounds 1, 18-24. The products were used directly in the next reaction.

References:

Wu, Guolin;Wang, Haixia;Zhou, Wenhui;Zeng, Bihua;Mo, Wenhui;Zhu, Kejie;Liu, Rong;Zhou, Jia;Chen, Ceshi;Chen, Haijun [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 12,p. 3321 - 3344] Location in patent:supporting information

FullText