ChemicalBook CAS DataBase List 3-Amino-5-bromopyridine

3-Amino-5-bromopyridine synthesis

6synthesis methods

Product Name:3-Amino-5-bromopyridine
CAS Number:13535-01-8
Molecular formula:C5H5BrN2
Molecular Weight:173.01

15862-30-3
138 suppliers
$11.00/250mg

13535-01-8
381 suppliers
$3.00/1g

Yield:13535-01-8 96%

Reaction Conditions:

with tetrahydroxydiboron;palladium on activated charcoal;water in acetonitrile at 50; for 24 h;Inert atmosphere;

Steps:

32 Example 32Synthesis of 5-bromo-3-aminopyridine
5-Bromo-3-nitropyridine (0.6mmol, 121.8mg), water (6mmol, 108.0mg), Pd/C (0.03mmol, 6.4mg) and tetrahydroxydiboron (1.98mmol, 177.5mg), acetonitrile ( 1mL), reacted at 50 C for 24h under nitrogen protection, monitored the reaction by TLC, added 10mL water, extracted with ethyl acetate (10mL×3), combined the organic phases, dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure, and separated by column chromatography ( V petroleum ether: V ethyl acetate=3:1) to obtain 99.7 mg of a white solid, that is, the target compound is obtained with a yield of 96%.

References:

Yichang Shang Nuode Bio-pharmaceutical Technology Co., Ltd.;Zhou Haifeng;Zhou Yanmei;Pi Danwei;Liu Qixing;Liu Sensheng CN106800493, 2020, B Location in patent:Paragraph 0185-0188

FullText

28733-43-9 Synthesis