ChemicalBook CAS DataBase List 5-Bromo-2-thiophenecarboxylic acid

5-Bromo-2-thiophenecarboxylic acid synthesis

13synthesis methods

Product Name:5-Bromo-2-thiophenecarboxylic acid
CAS Number:7311-63-9
Molecular formula:C5H3BrO2S
Molecular Weight:207.05

4701-17-1 Synthesis

4701-17-1
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$6.00/1g

7311-63-9
329 suppliers
$5.00/250mg

Yield:7311-63-9 85%

Reaction Conditions:

with potassium permanganate in acetone at 0 - 20; for 3 h;

Steps:

4.2 5-Bromothiophene-2-carboxylic acid (7)
To a solution of compound 6 (2 mmol) in acetone (15 mL) was added KMnO₄ (0.38 g, 2.4 mmol) in batches at 0 °C. The mixture was stirred at r.t. for 3 h. After it was fully reacted, the mixture was filtrated and filtrate was concentrated under vacuum. The residue was purified by column chromatography. Yield: 85%; ¹H NMR (500 MHz, CDCl₃) δ 7.64 (d, J = 4.5 Hz, 1H), 7.11 (d, J = 4.5 Hz, 1H). ESI-MS: m/z = 205 [M - H]^-.

References:

Zhan, Wenhu;Che, Jinxin;Xu, Lei;Wu, Yizhe;Hu, Xiaobei;Zhou, Yubo;Cheng, Gang;Hu, Yongzhou;Dong, Xiaowu;Li, Jia [European Journal of Medicinal Chemistry,2019,vol. 180,p. 72 - 85] Location in patent:supporting information

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527-72-0 Synthesis