ChemicalBook CAS DataBase List 3-Chloropropyne

3-Chloropropyne synthesis

9synthesis methods

Product Name:3-Chloropropyne
CAS Number:624-65-7
Molecular formula:C3H3Cl
Molecular Weight:74.51

2978-58-7 Synthesis

2978-58-7
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$12.00/1g

624-65-7
368 suppliers
$25.00/5mL

Yield:624-65-7 97.98%

Reaction Conditions:

with 3,5-dichlorobenzoyl chloride;potassium carbonate in N,N-dimethyl-formamide at 20; for 5 h;Time;Reagent/catalyst;

Steps:

1-3 Example 1

Put 209.50 g of 3,5-dichlorobenzoyl chloride, 83.16 g of 3-amino-3-methyl-1-butyne, and 419.5 g of DMF (N,N-dimethylformamide) into the reactor, and start stirring , The temperature was raised to 20°C, 21.1g of potassium carbonate, 1.57g of cyclodextrin, and 4.72g of octyldodecanol xyloside were added to the reaction kettle and reacted for 5 hours. After the reaction was completed, 82.17g of water was added to the reaction solution, and two Chloroethane 246.52g, stand for stratification, add the stratified organic phase to a sulfuric acid solution with a concentration of 2.0mol/L3.0mol/L, adjust the pH to 67, cool to -5 and stir for 2 hours. Centrifugal filtration to obtain 250.96g of propargyl chloride product,The yield is 97.98%, and the purity is 99.15%

References:

CN112661660,2021,A Location in patent:Paragraph 0020-0021; 0022-0023; 0024-0025; 0026-0031