ChemicalBook CAS DataBase List 3-Hydroxy-6-methylpyridine

3-Hydroxy-6-methylpyridine synthesis

12synthesis methods

Product Name:3-Hydroxy-6-methylpyridine
CAS Number:1121-78-4
Molecular formula:C6H7NO
Molecular Weight:109.13

55270-47-8
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$65.00/100mg

1121-78-4
292 suppliers
$6.00/5g

Yield:1121-78-4 84%

Reaction Conditions:

with L-Selectride in tetrahydrofuran for 24 h;Reflux;Inert atmosphere;chemoselective reaction;

Steps:

Demethylation of Methoxypyridines; General Procedure:
General procedure: Toa solution of 1 (1.00 mmol) in THF (7.0 mL) was added L-selectride(1 M in THF, 3.0 mL, 3.00 mmol, 3 equiv) under an argonatmosphere. After being refluxed and monitored by TLC, thereaction mixture was quenched with MeOH and evaporated invacuo. The residue was purified by silica gel column chromatographyto give the desired compound 2.

References:

Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo [Synlett,2019,vol. 30,# 8,p. 951 - 954]

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3430-13-5 Synthesis