ChemicalBook CAS DataBase List (3-NITROPHENYL)ACETIC ACID METHYL ESTER

(3-NITROPHENYL)ACETIC ACID METHYL ESTER synthesis

13synthesis methods

Product Name:(3-NITROPHENYL)ACETIC ACID METHYL ESTER
CAS Number:10268-12-9
Molecular formula:C9H9NO4
Molecular Weight:195.17

67-56-1 Synthesis

67-56-1
731 suppliers
$7.29/5ml-f

1877-73-2
200 suppliers
$24.00/1g

10268-12-9
80 suppliers
$55.00/1g

Yield: 100%

Reaction Conditions:

with chloro-trimethyl-silane at 20; for 18 h;

Steps:

118
Example 118 N- (3- {1-METHYL-2- [4- (2-METHYL-5-QUINOLINYL)-1-PIPERAZINYL] ETHYL} PHENYL) acetamide (E118) Methyl (3-nitrophenyl) acetate; Trimethylsilyl chloride (5.6 mL, 2.0 equiv. ) was added to a stirred solution of (3- nitrophenyl) acetic acid (4.0 g) in methanol (60 ML). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%). 1H-NMR (300 MHz, CDCI3) 8 (ppm): 8. 15 (s, 1H), 8.07 (d, 1H), 7.60 (d, 1H), 7.47 (t, 1H), 3. 85 (s, 2H), 3.80 (s, 3H).

References:

GLAXO GROUP LIMITED WO2005/14552, 2005, A1 Location in patent:Page/Page column 80

621-50-1 Synthesis