ChemicalBook CAS DataBase List 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE synthesis

6synthesis methods

Product Name:4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
CAS Number:438056-69-0
Molecular formula:C10H12N2O2
Molecular Weight:192.21

446292-04-2 Synthesis

446292-04-2
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438056-69-0
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Yield:438056-69-0 97.8%

Reaction Conditions:

with Pd/C;hydrogen in ethanol at 60; under 3000.3 Torr; for 3 h;Autoclave;

Steps:

4 Example 4:Preparation of 4-(4-aminophenyl)-3-morpholinone

1.57 g of 4-(4-aminophenyl)-3-morpholinone was added to the autoclave,An additional 0.37 g of palladium on carbon was added followed by 20 mL of absolute ethanol.After replacing the air in the vessel with hydrogen for three times, the oil bath is heated under hydrogen conditions.The mid-term hydrogen pressure is 0.4 MPa, the oil bath temperature is 60 ° C, and the stirring reaction is 3 h.The target product rivaroxaban intermediate 4-(4-aminophenyl)-3-morpholinone was obtained.After completion of the reaction, palladium carbon was removed by suction filtration, and the filtrate was concentrated under reduced pressure.Recrystallization from ethanol gives 4-(4-aminophenyl)-3-morpholinone,The yield was 97.8%.

References:

CN104788444,2018,B Location in patent:Paragraph 0041; 0042; 0043; 0044

109-11-5 Synthesis