ChemicalBook CAS DataBase List 4,5-Dichloro-2-octyl-isothiazolone

4,5-Dichloro-2-octyl-isothiazolone synthesis

3synthesis methods

Product Name:4,5-Dichloro-2-octyl-isothiazolone
CAS Number:64359-81-5
Molecular formula:C11H17Cl2NOS
Molecular Weight:282.23

Add 200 g of ethyl acetate and 23.6 g (0.1 mol) of N,N'-dimethyl-3,3'-dithiodipropionamide into a 500ml four-neck flask equipped with a thermometer and a stirrer, stir and mix, and control The reaction temperature was 15° C., 1.8 g of thionyl chloride (15.1 mmol) was added to the four-neck flask, and the mixture was stirred for 10 min.21.3g (0.3mol) of chlorine gas was introduced into the reaction system, the mixture was stirred for 5h to react, and 27.1g of 4,5-Dichloro-2-octyl-isothiazolone was obtained by filtration and separation. The yield was 84.9%.

33312-01-5 Synthesis

33312-01-5
28 suppliers
inquiry

64359-81-5
254 suppliers
$6.00/1g

Yield:64359-81-5 91%

Reaction Conditions:

with trichlorophosphate in acetic acid butyl ester at 10 - 40; for 2 h;Temperature;

Steps:

1-4

Add 200 mL of butyl acetate into a round bottom flask with an exhaust gas absorption device, then add the above intermediate 3,3'-dithiodioctylpropionamide, and slowly drop 100 g of phosphorus oxychloride at 10°C. After the dripping is completed and the gas no longer comes out, the ice bath is removed, and the temperature is raised to 40° C. to continue the reaction for 2 hours. After the reaction, the reactor was cooled to 5°C, and 5% sodium bicarbonate solution was slowly dropped to neutrality. After separating the water layer, the solvent was dried off and recrystallized with methanol to obtain a white solid.It is 4,5-dichloro-2-n-octyl-3-isothiazolinone, the solid weight is 94.55g, the yield is 91%,

References:

CN113582941,2021,A Location in patent:Paragraph 0032-0033; 0035; 0036; 0038; 0039; 0041; 0042; ...

26530-20-1 Synthesis

26530-20-1
285 suppliers
$38.00/1g

64359-81-5
254 suppliers
$6.00/1g

References

33312-01-5 Synthesis

33312-01-5
28 suppliers
inquiry

64359-81-5
254 suppliers
$6.00/1g

26530-20-1 Synthesis

26530-20-1
285 suppliers
$38.00/1g

References

4,5-Dichloro-2-octyl-isothiazolone Related Search:

2-Octyl-2H-isothiazol-3-one 2-Methyl-4-isothiazolin-3-one Dichloroacetonitrile 2-Methyl-4-isothiazolin-3-one hydrochloride Isothiazolinones thiazol-3-one Thiazole Isothiazole