ChemicalBook CAS DataBase List 4-BROMO-2-FLUOROBENZAMIDE

4-BROMO-2-FLUOROBENZAMIDE synthesis

4synthesis methods

Product Name:4-BROMO-2-FLUOROBENZAMIDE
CAS Number:292621-45-5
Molecular formula:C7H5BrFNO
Molecular Weight:218.02

105942-08-3 Synthesis

105942-08-3
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$7.00/5g

292621-45-5
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$35.00/250mg

Yield:292621-45-5 98%

Reaction Conditions:

with aluminum oxide;methanesulfonate at 120; for 0.5 h;

Steps:

Charge a flask with acidic alumina (Al₂O₃) (3.03 g, 29.718 mmol) and methanesulfonic acid (10 mL). Heat the resulting solution to 12O⁰C, and add 4-bromo-2-fluorobenzonitrile (2.00 g, 9.999 mmol) in one portion. Stir the resulting mixture for 30 minutes, then cool the reaction to room temperature and pour it into water (50 mL). Extract the aqueous mixture with dichloromethane (3 x 30 mL). Combine the organic extracts; dry(Na₂SO₄); remove the solids by filtration; and concentrate the filtrate in vacuo, affording 2.14 g (98%) 4-bromo-2-fluoro-benzamide as a white solid. ¹HNMR (DMSO-U₅) δ 7.706 (d, 2H, J = 21.1 Hz), 7.598 (dd, IH, J= 1.9, 10.1 Hz), 7.557 (dd, IH, J= 8.0, 8.0 Hz), 7.446 (ddd, IH, J= 0.4, 1.9, 8.1 Hz).

References:

WO2007/87488,2007,A2 Location in patent:Page/Page column 24

112704-79-7 Synthesis