4-(TRIFLUOROMETHYL)DIPHENYL ETHER synthesis
- Product Name:4-(TRIFLUOROMETHYL)DIPHENYL ETHER
- CAS Number:2367-02-4
- Molecular formula:C13H9F3O
- Molecular Weight:238.21
128796-39-4
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$10.00/5g
108-95-2
717 suppliers
$14.00/25g
2367-02-4
58 suppliers
$29.89/1g
Yield: 97%
Reaction Conditions:
with copper diacetate;triethylamine in dichloromethane at 0 - 5; for 4 h;Sonication;Green chemistry;
Steps:
General procedure: Naphthylboronic acid (0.25 g, 1.5 mmol) was added with 0.094 g of phenol (1.0 mmol) to 15 mL of DCM. Copper(II) acetate (0.36 g, 2.0 mmol) was then added along with triethylamine (0.5g, 5.0 mmol), and the dismembrator horn placed in the reaction vessel. The sonicator was set to 55 watts and the reaction was allowed to proceed for 4 hours (1 minute pulse with a 3 second rest). Post reaction, the product was isolated by column chromatography. Product yields were determined by weight and purity was confirmed by GC/MS and NMR.
References:
Musolino, Bryan J.;Kabalka, George W. [Heterocycles,2015,vol. 90,# 1,p. 271 - 297]
402-54-0
176 suppliers
$15.00/1 g
108-95-2
717 suppliers
$14.00/25g
2367-02-4
58 suppliers
$29.89/1g