Hydrocinnamoyl chloride synthesis
- Product Name:Hydrocinnamoyl chloride
- CAS Number:645-45-4
- Molecular formula:C9H9ClO
- Molecular Weight:168.62
501-52-0
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645-45-4
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Yield:645-45-4 100%
Reaction Conditions:
with oxalyl dichloride in dichloromethane at 20;
Steps:
3-Phenylpropanoyl chloride (74).
3-Phenylpropanoyl chloride (74). A 200 mL flask fitted with a stir-bar and septum with an Ar inlet was charged with hydrocinnamic acid (5.00 g, 33.3 mmol), DMF (0.1 mL), and CH2CI2 (30 mL). To the resultant solution was added (COCI)2 (2M in CH2CI2, 20.0 mL, 40.0 mmol) over 30 min. The mixture stirred overnight at rt, and then was concentrated in vacuo to give 5.9 g of 74 as a yellow oil (100%). HPLC analysis (15:10:75 H2O:A1 :MeOH) showed a purity of 99% with a retention time of 5.3 min.
References:
WO2013/101911,2013,A2 Location in patent:Page/Page column 57
16537-10-3
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140-10-3
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645-45-4
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