ChemicalBook CAS DataBase List Idarubicin

Idarubicin synthesis

3synthesis methods

Product Name:Idarubicin
CAS Number:58957-92-9
Molecular formula:C26H27NO9
Molecular Weight:497.49

23541-50-6 Synthesis

23541-50-6
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: potassium carbonate; triflic azide / dichloromethane; water; methanol
2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
2.2: pH 2.5 / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine; pyridine / dmap / 1 h / 0 - 20 °C
4.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran

References:

Synbias Pharma Ltd. EP2518077, 2012, A1

FullText

5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-7-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-, (7S,9S)-

60660-74-4
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58957-92-9
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References

60660-75-5 Synthesis

(7S,9S)9-ACETYL-7,8,9,10-TETRAHYDRO-6,7,9,11-TETRAHYDROXY-5,12-NAPHTACENEDIONE

60660-75-5
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$160.00/2.5mg

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References

Idarubicin Related Search:

p-Anisidine p-Anisaldehyde Acetylacetone Daunorubicin 6-Aminocaproic acid Acetyl chloride Anisole Glycine Enalaprilat Idarubicin hydrochloride