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ChemicalBook CAS DataBase List MK8245

MK8245 synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / Reflux; Inert atmosphere; Large scale reaction
1.2: 1.92 h / Reflux; Inert atmosphere; Large scale reaction
2.1: 18 h / 135 °C / neat (no solvent)
3.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 2.83 h / 55 - 58 °C / Inert atmosphere; Large scale reaction
4.1: formic acid / 2 h / 95 °C / Inert atmosphere; Large scale reaction

References:

Girardin, Melina;Dolman, Sarah J.;Lauzon, Sophie;Ouellet, Stephane G.;Hughes, Greg;O'Shea, Paul D.;Fernandez, Paul;Zhou, George [Organic process research and development,2011,vol. 15,# 5,p. 1073 - 1080]

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