ChemicalBook CAS DataBase List Zaleplon

Zaleplon synthesis

5synthesis methods

Product Name:Zaleplon
CAS Number:151319-34-5
Molecular formula:C17H15N5O
Molecular Weight:305.33

96605-66-2 Synthesis

N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide

96605-66-2
192 suppliers
$16.00/1g

16617-46-2 Synthesis

16617-46-2
473 suppliers
$6.00/5g

151319-34-5
3 suppliers
$65.00/1mg

Yield:151319-34-5 100 %Chromat.

Reaction Conditions:

with heptafluorobutyric Acid in water;butanone at 20;Product distribution / selectivity;

Steps:

2
Example 2; [0102] N- [3- [3- (dimethylamino)-l-oxo-2-propenyl] phenyl] -N-ethylacetamide (1.3 g), 3- amino-4-cyanopyrazole (0.54 g) were weighed into a 50 mL Erlenmeyer flask containing a magnetic stir bar. Water (17 mL), 2-butanone (17 mL) and of heptafluorobutyric acid (0.5 mL) were added to form the two phases. The two-phase mixture was stirred vigorously at room temperature and sampled for HPLC (50 gL each phase/100 mL methanol) at 30 minutes, 60 minutes, 90 minutes, and after stirring overnight. The area percents for zaleplon were 55. 0 %, 77.5 %, 86.7 % and 100 % at the stated time intervals, respectively.

References:

MALLINCKRODT INC. WO2005/70931, 2005, A1 Location in patent:Page/Page column 12

98-86-2 Synthesis